A Study of Serum Ceruloplasmin in Psoriasis and Its Correlation with Disease Severity

Psoriasis is a common chronic persistent inflammatory skin disorder distinguished by hyperproliferation and reduced differentiation of keratinocytes. 2-3% of the population is affected by this inflammatory skin disease. Biomarkers could be relevant for distinction between the different clinical variants of the disease, for assessment of disease activity and severity, and for prediction of the outcome of a therapeutic intervention for psoriasis. In the present study, serum ceruloplasmin levels were estimated in patients with psoriasis and a group of healthy controls. In addition, the correlation between ceruloplasmin levels and the severity of the disease was evaluated. The mean ceruloplasmin levels of cases was found to be higher compared to controls and it was statistically significant (p<0.0005). There was a mild negative correlation between ceruloplasmin levels and Psoriasis Area and Severity Index (PASI). In conclusion, ceruloplasmin could serve as a biomarker of psoriasis but not as a marker of psoriasis severity.